SEND Explorer offers the option to enable Dunnett’s test for variability analysis. This is a post-ANOVA pairwise test for statistical significance vs. control. For each distinct test code and timepoint, if the overall ANOVA is significant at the 5% level, Dunnett's test is carried out for each treated group vs control to assess statistical significance at the 5% and 1% level. Keep in mind that Dunnett’s test results in SEND Explorer may not align exactly with the CRO study report tables due to differences in methodology and the final study report should be considered as the definitive source for the study.
Enabling/Disabling Dunnett's Test
Starting with SEND Explorer V12, Dunnett's test is enabled by default. Only administrators can enable or disable Dunnett's test, using the steps below.
1 | Login to SEND Explorer as an administrator. |
2 | Click on the Admin hyperlink next to your name in the upper right-hand corner of the main screen. |
3 | Click on the Configuration button on the Administrator Dashboard. |
4 | Scroll down to locate the Features section. |
5 | To enable Dunnett's test, check the checkbox next to Enable ANOVA/Dunnett's Test. To disable, uncheck the checkbox. |
6 | Click on the Save button at the top of the Administrator Dashboard. |
Viewing Dunnett's Test Results in SEND Explorer
Dunnett's test results can be added to any Summary View for numeric endpoints in SEND Explorer. Summary Views can be accessed from the Summary button for any numeric domain displayed in grid view, and Summary by Timepoint and Summary by Test Code are the default view for Laboratory Tests (LB) and Organ Weights (OM) respectively, from the easy button links on the SEND Explorer Dashboard.
To add Dunnett's test results to Summary by Timepoint, Summary by Test Code or Summary by Tissue (organ weight data only), click on the Stats button from the top menu bar and select the checkbox next to Dunnett's Test. Dunnett's test results will then display for each treated group included in the display, along with any other summary measures (Mean, Standard Deviation, N).
Results can be filtered by Dunnett's test values in the Summary by Timepoint, Summary by Test Code and Summary by Tissue views.
To filter the display based on Dunnett's test results for Summary by Timepoint, click the filter icon in the top row of the summary view (the mouse-over text says "Summary Page Filters"). Then check the checkboxes under ANOVA/Dunnett's Test Filters as desired.
For Summary by Test Code, where distinct endpoints appear as separate columns, click on the Select Columns, then Groups. Select any ANOVA/Dunnett's test option desired to filter the display.
For Summary by Group, Dunnett's flags can be added to the display by clicking the checkbox for Dunnett's Test under Options on the left-hand side of the screen.
